WhitinsvilleWX Posted June 8, 2021 Share Posted June 8, 2021 21 minutes ago, NorEastermass128 said: It’s the Blues series all over again. Tough night all around. Rask is having a horrible game too. Link to comment Share on other sites More sharing options...
powderfreak Posted June 8, 2021 Share Posted June 8, 2021 19 minutes ago, WhitinsvilleWX said: Tough night all around. Rask is having a horrible game too. Not done yet though! They keep getting so many chances, they can do it. Red Sox with a win, too. Link to comment Share on other sites More sharing options...
WhitinsvilleWX Posted June 8, 2021 Share Posted June 8, 2021 6 minutes ago, powderfreak said: Not done yet though! They keep getting so many chances, they can do it. Red Sox with a win, too. Eh 3 minutes left. I doubt it Theyll have to win 2 in a row now. Tough road. Link to comment Share on other sites More sharing options...
powderfreak Posted June 8, 2021 Share Posted June 8, 2021 6 minutes ago, WhitinsvilleWX said: Eh 3 minutes left. I doubt it Theyll have to win 2 in a row now. Tough road. Good call. Just watching them get so many shots, figured another one of those 45 shots could go in. That extra skater last minute was frustrating. They should've been putting the puck on goal instead of passing it around looking for a perfect chance. Throw it at the goalie with traffic in front and see what happens. Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted June 8, 2021 Share Posted June 8, 2021 2 hours ago, snowman21 said: Go look at Kyle Crick's slider. It's ridiculous trying to even hit a pitch with nearly 2 feet of horizontal movement - it doesn't even look real. He spins up to 3500 RPM which is crazy because I think high 2000s used to be the god benchmark that few could reach. Crazy. Very large webbed hands? Link to comment Share on other sites More sharing options...
DavisStraight Posted June 8, 2021 Share Posted June 8, 2021 1 hour ago, NorEastermass128 said: It’s the Blues series all over again. They'll win the next two, no worries Link to comment Share on other sites More sharing options...
DavisStraight Posted June 8, 2021 Share Posted June 8, 2021 1 hour ago, WhitinsvilleWX said: Tough night all around. Rask is having a horrible game too. Rask is injured, shouldn't have been playing, hope he sits next game out, Swaymann can get it done. Link to comment Share on other sites More sharing options...
dendrite Posted June 8, 2021 Share Posted June 8, 2021 1 hour ago, STILL N OF PIKE said: Wow, that moves like it’s a whiffle ball https://www.si.com/mlb/2021/06/04/sticky-stuff-is-the-new-steroids-daily-cover Link to comment Share on other sites More sharing options...
mreaves Posted June 8, 2021 Share Posted June 8, 2021 12 hours ago, HIPPYVALLEY said: I'll just leave this here for baseball fans wondering about the spectacular pitching performances this year. https://www.si.com/mlb/2021/06/04/sticky-stuff-is-the-new-steroids-daily-cover?utm_source=pocket-newtab 6 minutes ago, dendrite said: https://www.si.com/mlb/2021/06/04/sticky-stuff-is-the-new-steroids-daily-cover Hippy beat you to it 1 Link to comment Share on other sites More sharing options...
dendrite Posted June 8, 2021 Share Posted June 8, 2021 Just now, mreaves said: Hippy beat you to it 1 Link to comment Share on other sites More sharing options...
PhineasC Posted June 8, 2021 Share Posted June 8, 2021 Like I said, let the hitters compensate a little with doctored bats and PEDs. Link to comment Share on other sites More sharing options...
mreaves Posted June 8, 2021 Share Posted June 8, 2021 And the Habs are in to the Conference Finals! Completely unexpected. Not going to happen but how epic would a Montreal/Boston Stanley Cup final be? Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted June 8, 2021 Share Posted June 8, 2021 Yikes: Massive internet outage - Websites and apps around the world go dark Link to comment Share on other sites More sharing options...
HIPPYVALLEY Posted June 8, 2021 Share Posted June 8, 2021 21 minutes ago, RUNNAWAYICEBERG said: Yikes: Massive internet outage - Websites and apps around the world go dark A lot of news sites down. Link to comment Share on other sites More sharing options...
STILL N OF PIKE Posted June 8, 2021 Share Posted June 8, 2021 38 minutes ago, HIPPYVALLEY said: A lot of news sites down. Maybe related , most media relates this to a fastly Server that went “down” and effected many other companies that use their technology https://www.marketwatch.com/story/doj-says-millions-of-dollars-of-bitcoin-reclaimed-from-ransom-paid-to-colonial-pipeline-hackers-11623096838?mod=mw_more_headlines Link to comment Share on other sites More sharing options...
HIPPYVALLEY Posted June 8, 2021 Share Posted June 8, 2021 2 minutes ago, STILL N OF PIKE said: Maybe related https://www.marketwatch.com/story/doj-says-millions-of-dollars-of-bitcoin-reclaimed-from-ransom-paid-to-colonial-pipeline-hackers-11623096838?mod=mw_more_headlines A massive, crippling cyberattack is only a matter of time at this point. Imagine the panic if people all of a sudden couldn’t use credit cards or access their money with ATMs. Link to comment Share on other sites More sharing options...
dendrite Posted June 8, 2021 Share Posted June 8, 2021 3 minutes ago, HIPPYVALLEY said: A massive, crippling cyberattack is only a matter of time at this point. Imagine the panic if people all of a sudden couldn’t use credit cards or access their money with ATMs. Or post on FB, twitter, or IG. Gah, the horror. 1 1 Link to comment Share on other sites More sharing options...
STILL N OF PIKE Posted June 8, 2021 Share Posted June 8, 2021 19 minutes ago, HIPPYVALLEY said: A massive, crippling cyberattack is only a matter of time at this point. Imagine the panic if people all of a sudden couldn’t use credit cards or access their money with ATMs. It seems like it might be, hopefully it can be turned into a opportunity to upgrade cyber security $Maybe find a few experts to go on TV and talk up tighter internet restrictions And gosh maybe blame a little on MMGW and the strain it’s putting on the grid . Now besides my sense of humor at the opportunities this could present (given the future framework of society and pillars of social movements..(movements that may have been pure of intent before they were tarnished by the cesspool of politics ) that are set in stone, heavily funded and certainly designed to lever up emotion to ensure they become as large and gain popularity to exert as much influence on education and opinion molding as possible for *as long as possible* w/out getting better ) that it seems like a major cyber attack that causes enough damage to facilitate knee jerk change is at least 50/50 in next year Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted June 8, 2021 Share Posted June 8, 2021 26 minutes ago, dendrite said: Or post on FB, twitter, or IG. Gah, the horror. 2 Link to comment Share on other sites More sharing options...
STILL N OF PIKE Posted June 8, 2021 Share Posted June 8, 2021 Biogen (BIIB) got FDA approval $ on their Alzheimer’s Drug yesterday . Seems like a good thing. Biogen then named their price for year supply . 56,000$ , what a racket pricing in that industry is. However when you read how they stopped their phase 3 trials due to emerge and engage missing endpoints in intern analysis , They removed it from their pipeline , only to decide in fall 2019 that if you look at the data sideways (Biogen decided to reinterpret the data and say it was better (lol) they reapplied to FDA , got shutdown twice bc the results were based on divergent data , and then Now were miraculously just approved under agency’s accelerated approval pathway . Sounds really solid ..... sad actually . Advisory panel urged a no vote as recent as April 2021. https://www.alzforum.org/therapeutics/aducanumab https://www.statnews.com/2021/05/30/if-the-fda-approves-biogens-alzheimers-treatment-i-wont-prescribe-it/ Link to comment Share on other sites More sharing options...
WhitinsvilleWX Posted June 8, 2021 Share Posted June 8, 2021 59 minutes ago, STILL N OF PIKE said: Biogen (BIIB) got FDA approval $ on their Alzheimer’s Drug yesterday . Seems like a good thing. Biogen then named their price for year supply . 56,000$ , what a racket pricing in that industry is. However when you read how they stopped their phase 3 trials due to emerge and engage missing endpoints in intern analysis , They removed it from their pipeline , only to decide in fall 2019 that if you look at the data sideways (Biogen decided to reinterpret the data and say it was better (lol) they reapplied to FDA , got shutdown twice bc the results were based on divergent data , and then Now were miraculously just approved under agency’s accelerated approval pathway . Sounds really solid ..... sad actually . Advisory panel urged a no vote as recent as April 2021. https://www.alzforum.org/therapeutics/aducanumab https://www.statnews.com/2021/05/30/if-the-fda-approves-biogens-alzheimers-treatment-i-wont-prescribe-it/ Its not a great drug. The trial results were iffy at best. The problem is that there's nothing out there to treat it. There's a class of drugs called acetylcholinesterase inhibitors (Aricept patch), and a class called NMDA receptor antagonists (Namenda). Both of these are short term fixes that don't get to the root of the plaque problem. In the end its a way to stave off the inevitable. The problem is that the biology of Alzheimer’s is poorly understood. In order to find a good treatment, the biology needs to be worked out better. I don't blame Biogen per se. They're a good well run company. People are desperate for a treatment. The FDA will watch it pretty close. If it's shown there's not a benefit, they will pull it down the road. They haven't done that very often but I think there's a shift in the thinking. If they approve a drug that could be beneficial for these "unmet needs" but based on sketchy data, the path going forward will be to pull it if there's no benefit after its been on the market.. Pricings a tough one. A lot goes into it. One of the reasons drugs cost a lot in the US is because they are mandated to be cheap in other countries. There needs to be more balance. And as I've said before, what institutions charge pharma companies to run clinical trials is criminal. Patent law needs to change to. Starting a patent run time when the structure is published is wrong. The patent duration needs to run longer once its on the market. There wouldn't be the need to recoup investment in such a short timespan. There's no easy answer. 1 1 Link to comment Share on other sites More sharing options...
bch2014 Posted June 8, 2021 Share Posted June 8, 2021 17 minutes ago, WhitinsvilleWX said: Its not a great drug. The trial results were iffy at best. The problem is that there's nothing out there to treat it. There's a class of drugs called acetylcholinesterase inhibitors (Aricept patch), and a class called NMDA receptor antagonists (Namenda). Both of these are short term fixes that don't get to the root of the plaque problem. In the end its a way to stave off the inevitable. The problem is that the biology of Alzheimer’s is poorly understood. In order to find a good treatment, the biology needs to be worked out better. I don't blame Biogen per se. They're a good well run company. People are desperate for a treatment. The FDA will watch it pretty close. If it's shown there's not a benefit, they will pull it down the road. They haven't done that very often but I think there's a shift in the thinking. If they approve a drug that could be beneficial for these "unmet needs" but based on sketchy data, the path going forward will be to pull it if there's no benefit after its been on the market.. Pricings a tough one. A lot goes into it. One of the reasons drugs cost a lot in the US is because they are mandated to be cheap in other countries. There needs to be more balance. And as I've said before, what institutions charge pharma companies to run clinical trials is criminal. Patent law needs to change to. Starting a patent run time when the structure is published is wrong. The patent duration needs to run longer once its on the market. There wouldn't be the need to recoup investment in such a short timespan. There's no easy answer. Isn’t there still some question as to whether the plaque is actually the cause of Alzheimer’s? 1 Link to comment Share on other sites More sharing options...
WhitinsvilleWX Posted June 8, 2021 Share Posted June 8, 2021 1 minute ago, bch2014 said: Isn’t there still some question as to whether the plaque is actually the cause of Alzheimer’s? That too. There's also vascular dementia. What used to be called "hardening of the arteries". Nothing much to be done there either. Everyone wants a fix to all the ills. Some things just cant be fixed but humans want them to be. Medical science can only do so much. 1 Link to comment Share on other sites More sharing options...
CoastalWx Posted June 8, 2021 Share Posted June 8, 2021 House 1 Link to comment Share on other sites More sharing options...
WhitinsvilleWX Posted June 8, 2021 Share Posted June 8, 2021 46 minutes ago, WhitinsvilleWX said: Its not a great drug. The trial results were iffy at best. The problem is that there's nothing out there to treat it. There's a class of drugs called acetylcholinesterase inhibitors (Aricept patch), and a class called NMDA receptor antagonists (Namenda). Both of these are short term fixes that don't get to the root of the plaque problem. In the end its a way to stave off the inevitable. The problem is that the biology of Alzheimer’s is poorly understood. In order to find a good treatment, the biology needs to be worked out better. I'll add: Part of the reason the FDA approved it is they were lobbied HARD! Not by Biogen, but buy AZ advocacy groups. I'll play both sides of the coin. On one hand, is it ethical to withhold a treatment for such a huge unmet medical need even if the data is sketchy. On the other hand, is it ethical to approve a drug that may not even work well (or even at all) and have government and private payers pay millions for reimbursement. Hard decision. But if I were the all powerful OZ, I wouldn't have approved it. Sets a bad precedent and somewhat reduces the efficacy requirements to that of snake oil. 2 Link to comment Share on other sites More sharing options...
STILL N OF PIKE Posted June 8, 2021 Share Posted June 8, 2021 17 minutes ago, WhitinsvilleWX said: I'll add: Part of the reason the FDA approved it is they were lobbied HARD! Not by Biogen, but buy AZ advocacy groups. I'll play both sides of the coin. On one hand, is it ethical to withhold a treatment for such a huge unmet medical need even if the data is sketchy. On the other hand, is it ethical to approve a drug that may not even work well (or even at all) and have government and private payers pay millions for reimbursement. Hard decision. But if I were the all powerful OZ, I wouldn't have approved it. Sets a bad precedent and somewhat reduces the efficacy requirements to that of snake oil. What , if any ..ties are there between “Big pharma” and the Az advocate groups funding or leadership Link to comment Share on other sites More sharing options...
NorEastermass128 Posted June 8, 2021 Share Posted June 8, 2021 Alzheimer’s runs in my family on my dad’s side. It’s a horrible disease that I wouldn’t wish on anyone, not even my worst enemy. 2 Link to comment Share on other sites More sharing options...
Angus Posted June 8, 2021 Share Posted June 8, 2021 56 minutes ago, WhitinsvilleWX said: Pricings a tough one. A lot goes into it. One of the reasons drugs cost a lot in the US is because they are mandated to be cheap in other countries. There needs to be more balance. And as I've said before, what institutions charge pharma companies to run clinical trials is criminal. Patent law needs to change to. Starting a patent run time when the structure is published is wrong. The patent duration needs to run longer once its on the market. There wouldn't be the need to recoup investment in such a short timespan. Agree whole heartedly ... if folks truly understood (absorb the impact) the price differentials between not just drugs but hospital equipment - domestic versus foreign and the subsidization that goes on between markets there would be outrage. IMO pricing differently between a developing country and W. Europe/USA/Canada/Japan is completely justifiable and good business - I do alot of pricing work in my job and love to price on the margin - but the differentials between W. Europe and US in many cases is crazy. Link to comment Share on other sites More sharing options...
Chrisrotary12 Posted June 8, 2021 Share Posted June 8, 2021 1 hour ago, CoastalWx said: House Car? Link to comment Share on other sites More sharing options...
natedizel Posted June 8, 2021 Share Posted June 8, 2021 1 hour ago, Chrisrotary12 said: Car? Boat?? Link to comment Share on other sites More sharing options...
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