Brian5671 Posted November 9, 2020 Share Posted November 9, 2020 11 minutes ago, NorEastermass128 said: I’m a little more optimistic. At the very least, if we can get older and more vulnerable populations to vaccinate, we’ll see the CFR decrease dramatically. Maybe young, healthy people won’t vaccinate and will still get it. But they’ll recover and not be able to spread it to vaccinated older, vulnerable populations. exacty.... Link to comment Share on other sites More sharing options...
natedizel Posted November 9, 2020 Share Posted November 9, 2020 3 hours ago, Ginx snewx said: He was a so so pitcher for the Sox For most of his career he was. The 2004 post season was big for him. He won game 7 in alcs and game 4 of the world series. Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted November 9, 2020 Share Posted November 9, 2020 https://www.theguardian.com/world/2020/nov/09/what-has-pfizers-covid-vaccine-trial-found-and-is-this-a-breakthrough How excited should we be? Most experts agree that the results are exciting and excellent news, but the optimism should come with a note of caution: the results are preliminary, have been shared only by press release, and the trials are not yet complete. So far, 38,955 people have received two doses of the vaccine, and the team plan a further analysis of the results once a total of 164 confirmed Covid-19 cases have occurred among the participants. They will also follow participants for two years post-vaccination to explore long-term safety and whether it continues to provide protection. Link to comment Share on other sites More sharing options...
WhitinsvilleWX Posted November 9, 2020 Share Posted November 9, 2020 11 minutes ago, Lava Rock said: DNA vaccines and in this case mRNA vaccines would likely be taken up by myocytes (muscle cells of the arm). While not the optimal antigen presenting cells (APC), they have the proper co-stimulatory molecules on their surface to present the vaccine antigens to T cells. More potent APCs would be interstitial dendritic cells and these would also be present, albeit to lower levels then muscle cells. Unless there is a secretion signal sequence encoded as part of the expressed spike protein for extracellular transport, the majority of the vaccine would be expressed intracellularly and loaded into Class I MHC for cellular CD8 T cell responses, but some vaccine antigen can and will be dumped extracellularly which would elicit the antibody response. There may be some microtissue trauma from needle injection which causes some minor inflammation, aiding in recruitment of immune cells. mRNA degrades pretty quickly even during "normal" bodily gene expression, but I think I recall hearing this vax is delivered in a liposome which provides enhanced protection against degradation. I figured it would be presented by MHC rather than dumped, mostly. Dendritic cells would be a good candidate. Never thought of the myocyte as a good APC. Not sure about that one. But is is one of the first cell types the mRNA would encounter. It is a liposome prep so degradation would be slowed, you're right about that. Lots of unknowns. mRNA vaccine research has been around a long time. I thought there would be more MOA known by now. Link to comment Share on other sites More sharing options...
PhineasC Posted November 9, 2020 Share Posted November 9, 2020 LOL at all the sudden anti-vaxxers. Gonna need to get Fauci up there to tell the masked-up scared sheep this is a good vaccine and they can receive it. 1 2 Link to comment Share on other sites More sharing options...
Baroclinic Zone Posted November 9, 2020 Author Share Posted November 9, 2020 3 minutes ago, PhineasC said: LOL at all the sudden anti-vaxxers. Gonna need to get Fauci up there to tell the masked-up scared sheep this is a good vaccine and they can receive it. Where? Link to comment Share on other sites More sharing options...
tunafish Posted November 9, 2020 Share Posted November 9, 2020 8 minutes ago, PhineasC said: LOL at all the sudden anti-vaxxers. Gonna need to get Fauci up there to tell the masked-up scared sheep this is a good vaccine and they can receive it. That's a pretty black and white, broad stoke. One can believe in the steps and actions that reduce the risk of transmitting the virus AND also have a healthy skeptism of whatever vaccine is first to market. Also can you please elaborate on what "masked-up scared sheep" means? Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted November 9, 2020 Share Posted November 9, 2020 9 minutes ago, Baroclinic Zone said: Where? Faux Entertainment. Link to comment Share on other sites More sharing options...
Baroclinic Zone Posted November 9, 2020 Author Share Posted November 9, 2020 1 minute ago, RUNNAWAYICEBERG said: Faux Entertainment. I tried to watch that for a bit over the last several days, and it was like watching Martian TV. They're living in a completely different realm that all the other major networks. 1 1 Link to comment Share on other sites More sharing options...
PhineasC Posted November 9, 2020 Share Posted November 9, 2020 7 minutes ago, Baroclinic Zone said: I tried to watch that for a bit over the last several days, and it was like watching Martian TV. They're living in a completely different realm that all the other major networks. How does the media still have credibility with you at this point? It isn’t even a partisan issue. They are so terrible now. That includes Facebook and Twitter too. They are actively censoring what you are allowed to see. 1 Link to comment Share on other sites More sharing options...
Damage In Tolland Posted November 9, 2020 Share Posted November 9, 2020 We Fox 1 2 3 Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted November 9, 2020 Share Posted November 9, 2020 8 minutes ago, Baroclinic Zone said: I tried to watch that for a bit over the last several days, and it was like watching Martian TV. They're living in a completely different realm that all the other major networks. Which is why the courts agreed they are not a news organization. Link to comment Share on other sites More sharing options...
PhineasC Posted November 9, 2020 Share Posted November 9, 2020 Cuomo indicating he will “block” the vaccine from wide distribution. This kind of talk is causing skepticism for the vaccine in the minority communities hit the hardest by COVID. So stupid. More people will die. 1 Link to comment Share on other sites More sharing options...
Brian5671 Posted November 9, 2020 Share Posted November 9, 2020 2 minutes ago, PhineasC said: Cuomo indicating he will “block” the vaccine from wide distribution. This kind of talk is causing skepticism for the vaccine in the minority communities hit the hardest by COVID. So stupid. More people will die. yeah that really is partisan and dumb Link to comment Share on other sites More sharing options...
powderfreak Posted November 9, 2020 Share Posted November 9, 2020 15 minutes ago, PhineasC said: How does the media still have credibility with you at this point? It isn’t even a partisan issue. They are so terrible now. That includes Facebook and Twitter too. They are actively censoring what you are allowed to see. One would think truth and fiction wouldn't be a partisan issue either. After Donald Trump, we certainly do live in a world where lies don't matter. Blatantly false information repeated over and over. Leaders of other nation's are starting to see it too... if you peddle lies long enough, they start to become truth. Trump is an amazing business man and he remained on-brand and remains on-brand... he knows marketing that's for sure. And his brand went to war with the media resulting in what we have now. 1 Link to comment Share on other sites More sharing options...
weathafella Posted November 9, 2020 Share Posted November 9, 2020 “A lie goes halfway around the world before the truth sees daybreak”. Not sure of the exact words of the last sentence but you get the idea. Lying is more effective. If you have someone with the ability to lie and not at all be bothered internally they can make many believe them. 3 Link to comment Share on other sites More sharing options...
SouthCoastMA Posted November 9, 2020 Share Posted November 9, 2020 4 minutes ago, powderfreak said: After Donald Trump, we certainly do live in a world where lies don't matter. Blatantly false information repeated over and over. Leaders of other nation's are starting to see it too... if you peddle lies long enough, they start to become truth. It must be exhausting to try and cover every lie from the President, some tried but many failed. There was plenty of lying and gaslighting from both the media and the President. Both can be true. Biden will lie - but he will do so in a presidential manner and in an ideologically aligned manner that's acceptable to many activists disguised as journalists in the MSM. I just avoid all network/cable news stations for the most part. 1 1 Link to comment Share on other sites More sharing options...
TauntonBlizzard2013 Posted November 9, 2020 Share Posted November 9, 2020 No fans at Gillette at all this year.... pats don’t seem to happy. Seems like we aren’t following the science anymore in mass. Schools=good... outdoor stadium at 20% capacity= bad. Masks anywhere outdoors now? Just making shit up now Link to comment Share on other sites More sharing options...
NorEastermass128 Posted November 9, 2020 Share Posted November 9, 2020 4 minutes ago, TauntonBlizzard2013 said: No fans at Gillette at all this year.... pats don’t seem to happy. Seems like we aren’t following the science anymore in mass. Schools=good... outdoor stadium at 20% capacity= bad. Masks anywhere outdoors now? Just making shit up now At least the Pats are garbage this season. Takes the sting away a bit. Link to comment Share on other sites More sharing options...
RUNNAWAYICEBERG Posted November 9, 2020 Share Posted November 9, 2020 18 minutes ago, NorEastermass128 said: At least the Pats are garbage this season. Takes the sting away a bit. True but at least they have a W from a forfeitted game tonight. Link to comment Share on other sites More sharing options...
Cold Miser Posted November 9, 2020 Share Posted November 9, 2020 1 hour ago, TauntonBlizzard2013 said: No fans at Gillette at all this year.... pats don’t seem to happy. Seems like we aren’t following the science anymore in mass. Schools=good... outdoor stadium at 20% capacity= bad. Masks anywhere outdoors now? Just making shit up now If you are in before 9:30PM you are safe. 1 Link to comment Share on other sites More sharing options...
HIPPYVALLEY Posted November 9, 2020 Share Posted November 9, 2020 1 hour ago, Ginx snewx said: So is the MSM , no credibility at all. Oh, I know. We called them news networks but they are still an entertainment industry looking for ratings and profits. Link to comment Share on other sites More sharing options...
HIPPYVALLEY Posted November 9, 2020 Share Posted November 9, 2020 Nice super spreader activities. Link to comment Share on other sites More sharing options...
HoarfrostHubb Posted November 9, 2020 Share Posted November 9, 2020 This early Novie weather is so amazing. To walk at sunset in just a t shirt is the bomb 1 Link to comment Share on other sites More sharing options...
Whineminster Posted November 10, 2020 Share Posted November 10, 2020 On 11/5/2020 at 10:26 AM, amarshall said: IPAs have absolutely destroyed my stomach to the point where I'm almost gluten intolerant/sugar intolerant. I can't have an a tasty tasty IPA without getting severely bloated. I used to drink IPAs religiously. I can have a 9% Imperial stout with no effect. One IPA and I'm toast. Yup I had 2 IPAs and my stomach was junk, almost puked. Sinusitis FTW too from inflammation. I can have 10 vodka shots and feel 100 times better 1 Link to comment Share on other sites More sharing options...
NorEastermass128 Posted November 10, 2020 Share Posted November 10, 2020 So...the Pats just stink. Link to comment Share on other sites More sharing options...
512high Posted November 10, 2020 Share Posted November 10, 2020 1 minute ago, NorEastermass128 said: So...the Pats just stink. against an 0-8 team, they lose this game I'm all done watching them....... Link to comment Share on other sites More sharing options...
HoarfrostHubb Posted November 10, 2020 Share Posted November 10, 2020 8 minutes ago, 512high said: against an 0-8 team, they lose this game I'm all done watching them....... I think they had 20 or so on the injured list. But yeah. Weak offense. Defense is sputtering. QB is a mess and no one to throw to. Jets could easily win this which is embarrassing Link to comment Share on other sites More sharing options...
CoastalWx Posted November 10, 2020 Share Posted November 10, 2020 11 minutes ago, 512high said: against an 0-8 team, they lose this game I'm all done watching them....... Haven’t watched in weeks. 1 1 Link to comment Share on other sites More sharing options...
ORH_wxman Posted November 10, 2020 Share Posted November 10, 2020 Just deleted a bunch of the politics posts from last couple pages. Ya’ll need to go somewhere else to discuss. 1 1 Link to comment Share on other sites More sharing options...
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