There's even a stark difference between State College and Philipsburg. I graduated (and lived) from Penn State, and often made the trip on 322 back from State College to DuBois. It was always a journey of several microclimates.
When you travel from Hershey up to the Allegheny Plateau via 322, it gets increasingly more wintry over each successive mountain ridge.
1st Change: Slight change as you work your way up the hills from Harrisburg to Lewistown.
2nd Change: Seven Mountains (Ridge past Milroy)
3rd Change: The ridges around Tussey and between Centre Hall and Pleasant Gap
4th Change: The ridge that runs between State College and Port Matilda
5th Change: The ridge between Port Matilda and Philipsburg - runs to the NE to the Snowshoe area on 80.
6th Change: The Woodland area before Clearfield - always snowier
7th and BIGGEST change: Clearfield Mountain between Clearfield and DuBois. (The Rockton area.) Over 2,000 feet in elevation - HUGE microclimate (in all times of the year) that I spent years driving through. Lots of ice storms and heavier snow there - Thunderstorms were always way worse as well (hail storms common). I actually worked on top of that mountain and it snowed an inch in the 3rd week of JUNE.