Lava Rock

Gust to 38mph. Pretty wild atm.

Congrats

They just suck and there's never a good time for the surgery for me. Snowmobile season coming, so could wait till spring, but then cycling season starts again. I'm hoping it's not a failure but I've had that nagging off and on pain with dragging feeling. PCP said she felt it the other day when I coughed. No buldge that I can see so maybe she was feeling the hernia pushing against the mesh who knows

Oh brother. I'm looking at a third hernia surgery. My last repair from last year may have failed. Gotta call surgeon this week.

Yup. Didn't pay a dime for my doctorate. Taught undergrad lab courses which earned me the tuition waiver and got a 20K stipend every year from my advisor for 5 yrs. I actually lived a pretty good life financially while in grad school.

Spoke to some realtors last weekend. Same going on here. 10-15% above list

haven't bought any yet. Missed the train

Finger on the trigger to buy some stock, but not sure they are going to eclipse PFZ's 90% efficacy, although they do have the less rigid temp requirement for the vax. Plus, if mRNA tech works as well as it looks it might, their market cap should really take off given their whole platform is RNA based

Regarding limiting the # of daily skiers. Are places in VT, NH, ME going to do the same where they will only let so many on the mtn? Will you need to make a reservation and will season pass holders be given priority over day trippers? We've got our annual SR trip planned for Feb and will pick up a few other day trips throughout the season, but it's looking more like a PITA to make it worthwhile. I see lots more snowmobiling this season

Yep, she could have reported them

Wife had to scold two people on two different flights for setting off in flight bathroom smoke alarm due to vaping. Wtf. How hard up can you be?

I hope I never have to go to a "care" facility. Take me out to the woodshed

So Biden wants to shut down for 4-6 wks and says one of his scientists says we can emulate what Australia and NZ did. Really? That's not going to work and to even think the US is comparable to two islands in the southern hemisphere is ridiculous. it's a non-starter for so many reasons.

Odd,. reddit was also down today for a time

70F on the way home. Nuts

And she'd be cool with that as we put that out there as an option, but she's 100% certain in her mind that she doesn't and won't have covid so no need to get tested. Of course she's back at work this week flying around the country then heading to LAX to see her brother and sister next week. All the more reason to at least get tested. I have to be careful how I say things. Marriages sure can be challenging.

Wife wants to go to a friend's house for dinner. They are older (70s) and have a 30yr son at home. I told her unless we get tested, I really don't want to go. Not because I think they may give it to us, but we to them. I just don't think it's worth it to sit and have dinner with people in a tight house. My mom and sister told us not to come, not that we usually celebrate together anyways, but my wife gets pissy when I tell her we probably should stay home. Both her parents have passed on now and we'd usually be in LAX for the holidays, but not anymore. I think she just feels this need to have to be with people during the holidays. Wonder how many other spousal relationships are having a bit of tough time with decisions like this.

Must have some house renovations coming up

I think our Gov is biting at the bit for lockdowns.

what is the scientific explanation as to why cases increase with more mask use?

Apparently Maine is now the worst in the country for virus reproduction rate. Just exploding here.

Blew the doors off previous records. The CAR temp is usually their avg high in early july

DNA vaccines and in this case mRNA vaccines would likely be taken up by myocytes (muscle cells of the arm). While not the optimal antigen presenting cells (APC), they have the proper co-stimulatory molecules on their surface to present the vaccine antigens to T cells. More potent APCs would be interstitial dendritic cells and these would also be present, albeit to lower levels then muscle cells. Unless there is a secretion signal sequence encoded as part of the expressed spike protein for extracellular transport, the majority of the vaccine would be expressed intracellularly and loaded into Class I MHC for cellular CD8 T cell responses, but some vaccine antigen can and will be dumped extracellularly which would elicit the antibody response. There may be some microtissue trauma from needle injection which causes some minor inflammation, aiding in recruitment of immune cells. mRNA degrades pretty quickly even during "normal" bodily gene expression, but I think I recall hearing this vax is delivered in a liposome which provides enhanced protection against degradation.

yeah pfz manufactured and the govt prepaid for a bunch of doses months ago regardless if the trial failed. quite the gamble, but thankfully it appears to be a success

actually 660 million since the vax requires 2 doses.