Very high cholesterol runs in my family. I have been on statins since I turned 18 and my total cholesterol was already high 200s at that time even though I was as thin as a rail and played various sports. Never had any side effects, that I am aware of at least. Liver numbers always looked good.
My HDL remains too low and my LDL too high. My triglycerides have also spiked at various points, but I made some additional dietary changes and they recently dropped. Without statins, my cholesterol would be off the charts right now and I would be headed for a heart attack at a fairly young age.
I am not a fatty who eats three burgers a day, either. My body just makes too much of the stuff.
So I recommend the drugs to anyone dealing with high cholesterol who already has a decent diet, keeps their weight in check, and exercises.