I'm developing some chinks in the armor here in my mid 40s.....left shoulder is a bit iffy, as I had a small tear in the rorator cuff a couple of years ago that I just let heal....now I'm starting to get some "areas" in my knees....nothing severe, but enough to that I am a bit conscious of certain movements these days. Doesn't affect my squat or anything yet, since I wrap my knees.
None of this impairs my heavy lifts yet.
Back is still perfect, save for some occasional, mild inflamation down low.